Sulfatol Cleanser Emulsion

Pronunciation: sul-fa-SEE-ta-mide/yoor-EE-a
Generic Name: Sulfacetamide/Urea
Brand Name: Examples include Rosula Cleanser and Sulfatol Cleanser

Sulfatol Cleanser Emulsion is used for:

Treating certain skin conditions (eg, seborrheic dermatitis), dandruff, and certain bacterial infections of the skin. It may also be used for other conditions as determined by your doctor.

Sulfatol Cleanser Emulsion is a sulfonamide antibiotic. It works by killing bacteria, helping to shed scaly skin, and softening the skin.

Do NOT use Sulfatol Cleanser Emulsion if:

• you are allergic to any ingredient in Sulfatol Cleanser Emulsion


• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide


• you are taking methenamine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sulfatol Cleanser Emulsion:

Some medical conditions may interact with Sulfatol Cleanser Emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of lupus

Some MEDICINES MAY INTERACT with Sulfatol Cleanser Emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Silver-containing products (eg, silver sulfadiazine) because they may decrease Sulfatol Cleanser Emulsion's effectiveness


• Methenamine because it may increase the risk of Sulfatol Cleanser Emulsion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sulfatol Cleanser Emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sulfatol Cleanser Emulsion:

Use Sulfatol Cleanser Emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Sulfatol Cleanser Emulsion is for use on the skin only. Wash your hands before and immediately after using Sulfatol Cleanser Emulsion. Clean the affected area before applying Sulfatol Cleanser Emulsion. Wet skin and apply plenty of Sulfatol Cleanser Emulsion. Rub gently into the skin for 10 to 20 seconds to form a full lather, rinse completely, and pat dry.


• To clear up your infection completely, use Sulfatol Cleanser Emulsion for the full course of treatment. Keep using it even if you feel better in a few days.


• Sulfatol Cleanser Emulsion works best if it is used at the same time each day.


• Continue to use Sulfatol Cleanser Emulsion even if you feel well. Do not miss any doses.


• If you miss a dose of Sulfatol Cleanser Emulsion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sulfatol Cleanser Emulsion.

Important safety information:

• It may take several days for Sulfatol Cleanser Emulsion to work fully.


• Avoid getting Sulfatol Cleanser Emulsion in your eyes, nose, or mouth.


• Talk with your doctor before you use any other medicines or cleansers on your skin.


• Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Sulfatol Cleanser Emulsion only works against bacteria; it does not treat viral infections.


• Be sure to use Sulfatol Cleanser Emulsion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Sulfatol Cleanser Emulsion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Sulfatol Cleanser Emulsion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sulfatol Cleanser Emulsion while you are pregnant. It is not known if Sulfatol Cleanser Emulsion is found in breast milk after topical use. If you are or will be breast-feeding while you use Sulfatol Cleanser Emulsion, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Sulfatol Cleanser Emulsion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritation, stinging, or burning of the skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; fever; joint pain; red, swollen, or blistered skin; severe diarrhea; sores in the mouth; stomach cramps/pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Sulfatol Cleanser Emulsion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Sulfatol Cleanser Emulsion:

Store Sulfatol Cleanser Emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Sulfatol Cleanser Emulsion out of the reach of children and away from pets.

General information:

• If you have any questions about Sulfatol Cleanser Emulsion, please talk with your doctor, pharmacist, or other health care provider.


• Sulfatol Cleanser Emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sulfatol Cleanser Emulsion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Sulfatol Cleanser resources

• Sulfatol Cleanser Use in Pregnancy & Breastfeeding
• Sulfatol Cleanser Support Group
• 0 Reviews for Sulfatol - Add your own review/rating

Compare Sulfatol Cleanser with other medications

• Dandruff
• Seborrheic Dermatitis
• Secondary Cutaneous Bacterial Infections

Tyzeka

Pronunciation: tel-BIV-ue-deen
Generic Name: Telbivudine
Brand Name: Tyzeka

Lactic acidosis (high blood lactic acid levels) has occurred with similar medicines. This has sometimes been fatal. Check with your doctor at once if you feel very weak, tired, dizzy, lightheaded, or unusually cold (especially in the arms or legs). Check with your doctor at once if you develop unusual muscle pain, trouble breathing, fast or irregular heartbeat, or stomach pain with nausea and vomiting.

Severe and sometimes fatal liver problems have occurred with the use of similar medicines. Check with your doctor at once if you develop nausea, unusual stomach pain, loss of appetite, dark urine, pale stools, or yellowing of the eyes or skin.

Worsening of hepatitis B infection has occurred in patients who have stopped Tyzeka. Do not stop taking Tyzeka without checking with your doctor. If you need to stop taking it, your liver function will be monitored for at least several months after you stop treatment.

Tyzeka is used for:

Treating chronic hepatitis B infection in certain patients.

Tyzeka is a nucleoside analog reverse transcriptase inhibitor. It works by blocking the growth of the hepatitis B virus (HBV).

Do NOT use Tyzeka if:

• you are allergic to any ingredient in Tyzeka


• you have an enlarged liver, abnormal liver function tests, or high levels of lactic acid in the blood

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tyzeka:

Some medical conditions may interact with Tyzeka. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have another type of hepatitis, HIV, kidney problems, or if you are receiving dialysis


• if you have received an organ transplant (eg, liver transplant)


• if you have a history of muscle problems or nerve problems


• if you are also taking interferon alfa-2a

Some MEDICINES MAY INTERACT with Tyzeka. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Pegylated interferon alfa-2a or other interferons because the risk and severity of nerve problems (eg, peripheral neuropathy) may be increased


• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidneys

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tyzeka may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tyzeka:

Use Tyzeka as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Tyzeka comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tyzeka refilled.


• Take Tyzeka by mouth with or without food.


• Take Tyzeka on a regular schedule to get the most benefit from it. Taking Tyzeka at the same time each day will help you remember to take it.


• Continue to take Tyzeka even if you feel well. Do not miss any doses.


• If you miss a dose of Tyzeka, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tyzeka.

Important safety information:

• Tyzeka may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Tyzeka with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Do not suddenly stop taking Tyzeka. Your HBV infection may become worse.


• Tyzeka is not a cure for HBV infection. Remain under the care of your doctor.


• Tyzeka does not stop the spread of HBV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HBV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can.


• Tyzeka may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Tyzeka.


• Lab tests, including liver function, kidney function, and HBV blood tests, may be performed while you use Tyzeka. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Tyzeka with caution in the ELDERLY; they may be more sensitive to its effects.


• Tyzeka should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tyzeka while you are pregnant. It is not known if Tyzeka is found in breast milk. Do not breast-feed while taking Tyzeka.

Possible side effects of Tyzeka:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; cough; diarrhea; dizziness; headache; joint pain; mild stomach pain or upset; nausea; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased coordination or trouble walking; fainting; fast or irregular heartbeat; fever or persistent sore throat; loss of appetite; numbness, tingling, or burning in the arms or legs; pale stools; severe or persistent dizziness or lightheadedness; severe or persistent nausea or vomiting; severe or persistent tiredness or weakness; severe, persistent, or unusual stomach pain; stomach swelling; trouble breathing or shortness of breath; unusual cold feeling, especially in the arms or legs; unusual muscle pain, ache, tenderness, or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tyzeka side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Tyzeka:

Store Tyzeka at 77 degrees F (25 degrees C) in the original container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tyzeka out of the reach of children and away from pets.

General information:

• If you have any questions about Tyzeka, please talk with your doctor, pharmacist, or other health care provider.


• Tyzeka is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tyzeka. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tyzeka resources

• Tyzeka Side Effects (in more detail)
• Tyzeka Use in Pregnancy & Breastfeeding
• Tyzeka Drug Interactions
• Tyzeka Support Group
• 0 Reviews for Tyzeka - Add your own review/rating

• Tyzeka Prescribing Information (FDA)


• Tyzeka Consumer Overview


• Tyzeka Monograph (AHFS DI)


• Tyzeka Advanced Consumer (Micromedex) - Includes Dosage Information


• Telbivudine Professional Patient Advice (Wolters Kluwer)

Compare Tyzeka with other medications

• Hepatitis B

Tolectin 600

Generic Name: tolmetin (Oral route)

TOLE-met-in

Oral route(Tablet;Capsule)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Tolmetin is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Tolectin 600


• Tolectin DS

Available Dosage Forms:

• Tablet


• Capsule

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Tolectin 600

Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it.

This medicine is available only with your doctor's prescription.

Before Using Tolectin 600

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of tolmetin in children below 2 years of age. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of tolmetin in geriatric patients. However, elderly patients may be more sensitive to the effects of tolmetin than younger adults, and are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving tolmetin.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acenocoumarol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dicumarol


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Phenprocoumon


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention or body swelling) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• Hypertension (high blood pressure) or


• Kidney disease or


• Liver disease (e.g., hepatitis) or


• Stomach or intestinal ulcers or bleeding, history of or


• Stroke, history of—Use with caution. May make these conditions worse.

• Aspirin-sensitive asthma or


• Aspirin sensitivity, history of—This medicine should not be used in patients with these conditions.

• Heart surgery (e.g., coronary artery bypass graft [CABG])—This medicine should not be used to relieve pain right before or after the surgery.

Proper Use of tolmetin

This section provides information on the proper use of a number of products that contain tolmetin. It may not be specific to Tolectin 600. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

It is best to take this medicine on an empty stomach. However, if it upsets your stomach, you may take this medicine with an antacid that does not contain sodium bicarbonate.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules or tablets):
  
  • For osteoarthritis and rheumatoid arthritis:
    
    • Adults—At first, 400 milligrams (mg) three times a day. Your doctor may increase your dose as needed up to a total dose of 1800 mg per day.
    
    
    • Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. At first, 20 milligrams (mg) per kilogram (kg) of body weight per day, divided into smaller amounts that are taken three or four times a day. Your doctor may increase your dose as needed up to 30 mg per kg of body weight per day.
    
    
    • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Tolectin 600

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.

This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (such as steroids or a blood thinner).

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of the skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in the mouth or on the lips, or unusual tiredness or weakness.

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs; severe stomach pain; black, tarry stools; vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once.

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure.

Tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Tolectin 600 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Abdominal or stomach pain


• diarrhea


• dizziness


• headache


• nausea


• numbness or tingling in the arms or legs


• swelling


• trouble thinking, speaking, or walking


• vomiting


• weakness


• weight gain

Less common

• Black, tarry stools


• bladder pain


• blood in the vomit


• bloody or cloudy urine


• blurred or loss of vision


• burning feeling in the chest or stomach


• burning, itching, redness, or stinging of the skin


• chest pain


• difficult, burning, or painful urination


• disturbed color perception


• double vision


• frequent urge to urinate


• halos around lights


• indigestion


• lower back or side pain


• night blindness


• overbright appearance of lights


• severe or continuing stomach pain


• stomach upset


• tenderness in the stomach area


• tunnel vision

Rare

• Back or leg pains


• bleeding gums


• blistering, peeling, or loosening of the skin


• chills


• constipation


• cough or hoarseness


• dark urine


• decreased urine output


• difficulty with breathing


• difficulty with swallowing


• dilated neck veins


• extreme fatigue


• fast, irregular heartbeat


• feeling of discomfort


• fever


• general body swelling


• heartburn


• hives or welts


• increased thirst


• inflammation of the joints


• irregular breathing


• joint or muscle pain


• light-colored stools


• loss of appetite


• muscle aches


• nosebleeds


• pale skin


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• severe and continuing nausea


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swelling of the face, fingers, feet, or lower legs


• swollen, painful, or tender lymph glands in the neck, armpit, or groin


• tightness in the chest


• trouble with breathing


• unusual bleeding or bruising


• unusual tiredness or weakness


• upper right abdominal pain


• wheezing


• yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• belching


• bloated full feeling


• excess air or gas in the stomach or intestines


• lack or loss of strength


• passing gas


• stomach discomfort


• weight loss

Less common

• Continuing ringing or buzzing or other unexplained noise in the ears


• discouragement


• feeling sad or empty


• hearing loss


• irritability


• loss of interest or pleasure


• sleepiness


• tiredness


• trouble with concentrating


• trouble with sleeping

Rare

• Redness, swelling, or soreness of the tongue


• swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Tolectin 600 side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Tolectin 600 resources

• Tolectin 600 Side Effects (in more detail)
• Tolectin 600 Use in Pregnancy & Breastfeeding
• Drug Images
• Tolectin 600 Drug Interactions
• Tolectin 600 Support Group
• 0 Reviews for Tolectin 600 - Add your own review/rating

• Tolectin 600 MedFacts Consumer Leaflet (Wolters Kluwer)


• Tolmetin Prescribing Information (FDA)


• Tolectin Monograph (AHFS DI)


• Tolectin Concise Consumer Information (Cerner Multum)

Compare Tolectin 600 with other medications

• Back Pain
• Gout, Acute
• Inflammatory Conditions
• Osteoarthritis
• Pain
• Rheumatoid Arthritis
• Sciatica

Sargramostim

Generic Name: sargramostim (sar GRA moe stim)

Brand Names: Leukine

What is sargramostim?

Sargramostim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Sargramostim is used to increase white blood cells and help prevent serious infection in conditions such as leukemia, bone marrow transplant, and pre-chemotherapy blood cell collection. Sargramostim is for use in adults who are at least 55 years old.

Sargramostim may also be used for purposes not listed in this medication guide.

What is the most important information I should know about sargramostim?

You should not use this medication if you are allergic to sargramostim or to yeast. Sargramostim should not be used within 24 hours before or after you receive chemotherapy or radiation.

Before you receive sargramostim, tell your doctor if you have fluid retention (especially around your lungs), heart disease, high blood pressure, congestive heart failure, bone marrow cancer, a seizure disorder, liver or kidney disease, or a breathing disorder such as COPD or asthma.

Tell your caregiver right away if you feel dizzy, nauseated, light-headed, short of breath, or have a fast heartbeat, chest tightness, or trouble breathing when you inject this medication.

Call your doctor at once if you have any other serious side effects such as fever, chills, sore throat, flu symptoms, mouth sores, easy bruising or bleeding, and swelling or rapid weight gain.

Using sargramostim may increase your risk of developing other cancers. Ask your doctor about your individual risk.

What should I discuss with my healthcare provider before using sargramostim?

You should not use this medication if you are allergic to sargramostim or to yeast. Sargramostim should not be used within 24 hours before or after you receive chemotherapy or radiation.

To make sure you can safely use sargramostim, tell your doctor if you have any of these other conditions:

• 
  

  fluid retention;

  
  


• 
  

  a buildup of fluid around your lungs (also called pleural effusion);

  
  


• 
  

  bone marrow cancer;

  
  


• 
  

  heart disease, high blood pressure; congestive heart failure;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  liver or kidney disease; or

  
  


• 
  

  asthma, chronic obstructive pulmonary disease (COPD), or other breathing problems.

  
  

Using sargramostim may increase your risk of developing other cancers. Ask your doctor about your individual risk.

FDA pregnancy category C. It is not known whether sargramostim will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether sargramostim passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use sargramostim?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Sargramostim should not be used within 24 hours before or after you receive chemotherapy or radiation.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Sargramostim is injected into a vein or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

When injected into a vein, sargramostim must be given slowly. The IV infusion can take up to 24 hours to complete.

Use a different place on your stomach, thigh, or upper arm each time you give the injection under the skin. Just before you give the injection, apply an ice pack to the skin for one minute. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Sargramostim powder must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Do not shake the mixed medicine or it may foam. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with sargramostim. Your liver function will also need to be tested. Visit your doctor regularly.

Store the liquid medicine in the refrigerator, do not freeze. Protect from light. You may take the medicine out and allow it to reach room temperature before measuring your dose in a syringe. Then return the medicine to the refrigerator. Throw away any unused liquid after 20 days. After mixing sargramostim powder with a diluent, store in the refrigerator and use it within 6 hours. Do not freeze. Protect from light. If you have mixed the powder with bacteriostatic water, you may store this mixture in the refrigerator for up to 20 days.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of sargramostim.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, weakness, headache, fever, chills, skin rash, fast heart rate, or trouble breathing.

What should I avoid while using sargramostim?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Sargramostim side effects

Some people receiving a sargramostim injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, short of breath, or have a fast heartbeat, chest tightness, or trouble breathing during the injection. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  high fever, chills, sore throat, stuffy nose, flu symptoms;

  
  


• 
  

  white patches or sores inside your mouth or on your lips;

  
  


• 
  

  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  
  


• 
  

  swelling, rapid weight gain;

  
  


• 
  

  chest pain, fast or uneven heart rate;

  
  


• 
  

  weakness or fainting;

  
  


• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  painful or difficult urination;

  
  


• 
  

  dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


• 
  

  breathing problems; or

  
  


• 
  

  problems with vision, speech, balance, or memory.

  
  

Less serious side effects may include:

• 
  

  nausea, stomach pain, vomiting, diarrhea, loss of appetite;

  
  


• 
  

  tired feeling;

  
  


• 
  

  hair loss;

  
  


• 
  

  weight loss;

  
  


• 
  

  headache;

  
  


• 
  

  mild skin rash or itching;

  
  


• 
  

  bone pain;

  
  


• 
  

  joint or muscle pain; or

  
  


• 
  

  redness, swelling, or irritation where the injection was given.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sargramostim Dosing Information

Usual Adult Dose for Neutropenia Associated with Chemotherapy:

250 mcg/m2/day IV over a 4 hour period beginning on or around day 11 or 4 days following the completion of induction chemotherapy, if the day 10 bone marrow is hypoplastic with

Usual Adult Dose for Bone Marrow Transplantation -- Myeloid Reconstruction:

250 mcg/m2/day for 21 days as a 2 hour IV infusion beginning 2 to 4 hours after the autologous bone marrow infusion, at least 24 hours after the last dose of chemotherapy and 12 hours after the last dose of radiotherapy.

Usual Adult Dose for Bone Marrow Transplantation -- Failure or Engraftment Delay:

250 mcg/m2/day for 14 days as a 2 hour IV infusion. The dose can be repeated 7 days later if engraftment has not been achieved. If engraftment has not taken place after the second administration of sargramostim, a dose of 500 mcg/m2/day for 14 days may be administered beginning 7 days after the previous dose (14 days after the initial dose).

Usual Pediatric Dose for Aplastic Anemia:

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

8 to 32 mcg/kg/day IV or subcutaneously, administered once a day.

Usual Pediatric Dose for Bone Marrow Transplantation:

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

250 mcg/m2/day IV or subcutaneously, once a day for 21 days beginning 2 to 4 hours after the marrow infusion on day 0.

Usual Pediatric Dose for Neutropenia Associated with Chemotherapy:

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

3 to 15 mcg/kg/day IV or subcutaneously, each day for 14 to 21 days. Maximum dose: 30 mcg/kg/day or 1500 mcg/m2/day.

What other drugs will affect sargramostim?

Tell your doctor about all other medicines you use, especially:

• 
  

  lithium (Eskalith, Lithobid); or

  
  


• 
  

  a steroid such as prednisone (Meticorten, Sterapred), methylprednisolone (Medrol), dexamethasone (Decadron), and others.

  
  

This list is not complete and other drugs may interact with sargramostim. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More sargramostim resources

• Sargramostim Side Effects (in more detail)
• Sargramostim Use in Pregnancy & Breastfeeding
• Sargramostim Drug Interactions
• Sargramostim Support Group
• 0 Reviews for Sargramostim - Add your own review/rating

• sargramostim Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Sargramostim Professional Patient Advice (Wolters Kluwer)


• Sargramostim MedFacts Consumer Leaflet (Wolters Kluwer)


• Sargramostim Monograph (AHFS DI)


• Leukine Prescribing Information (FDA)


• Leukine Consumer Overview

Compare sargramostim with other medications

• Aplastic Anemia
• Bone Marrow Transplantation
• Bone Marrow Transplantation, Failure or Engraftment Delay
• Bone Marrow Transplantation, Myeloid Reconstruction
• Neutropenia Associated with Chemotherapy

Where can I get more information?

• Your doctor or pharmacist can provide more information about sargramostim.

See also: sargramostim side effects (in more detail)

Nabilone

NAB-i-lone

Commonly used brand name(s)

In the U.S.

• Cesamet

Available Dosage Forms:

• Capsule

Therapeutic Class: Antiemetic

Chemical Class: Cannabinoid

Uses For nabilone

Nabilone is used to treat the nausea and vomiting that may occur during treatment with cancer medicines. It is only used when other kinds of medicine for nausea and vomiting do not work.

Nabilone is only available with your doctor's prescription.

Before Using nabilone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nabilone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nabilone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies with nabilone have only been done in adult patients, and there is no specific information comparing use of nabilone in children with use in other age groups. Caution should be used in prescribing nabilone to children under the age of 18 years due to its mind and mood-altering effects.

Geriatric

Fast or pounding heartbeat, feeling faint or lightheaded, and unusual tiredness or weakness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of nabilone. Also, the effects nabilone may have on the mind may be of special concern in the elderly. Therefore, older people should be watched closely while taking nabilone.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of nabilone. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Drug abuse or dependence (or history of)—Dependence on nabilone may develop.

• Emotional problems or


• Heart disease or


• Low blood pressure or


• Manic or depressive states or


• Mental illness (severe) or


• Schizophrenia—Nabilone may make the condition worse.

• Kidney problems or


• Liver problems—Nabilone has not been studied in patients with these conditions.

Proper Use of nabilone

Take nabilone only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may lead to other medical problems because of an overdose.

Dosing

The dose of nabilone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nabilone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules):
  
  • For nausea and vomiting caused by cancer medicines:
    
    • Adults—Usually 1 or 2 milligrams (mg) twice a day. Your doctor will tell you how and when to take nabilone while you are taking your cancer medicine.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of nabilone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using nabilone

Nabilone will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you feel drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicines, including other narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking nabilone.

If you think you or someone else may have taken an overdose, get emergency help at once. Taking an overdose of nabilone or taking alcohol or CNS depressants with nabilone may cause severe mental effects. Symptoms of overdose include changes in mood; confusion; difficulty in breathing; hallucinations (seeing, hearing, or feeling things that are not there); nervousness or anxiety (severe); and fast or pounding heartbeat.

nabilone may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to nabilone before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem.

Nabilone may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

nabilone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Changes in mood


• confusion


• convulsions (seizures)


• delusions


• dizziness or fainting


• fast or pounding heartbeat


• hallucinations (seeing, hearing, or feeling things that are not there)


• mental depression


• nervousness or anxiety


• unusual tiredness or weakness (severe)

Symptoms of overdose

• Difficulty in breathing


• hallucinations (seeing, hearing, or feeling things that are not there)


• mental changes (severe)


• nervousness or anxiety (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Clumsiness or unsteadiness


• drowsiness


• dryness of mouth


• false sense of well-being


• headache

Less common or rare

• Blurred vision or any changes in vision


• dizziness or lightheadedness, especially when getting up from a lying or sitting position—more common with high doses


• loss of appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: nabilone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More nabilone resources

• Nabilone Side Effects (in more detail)
• Nabilone Dosage
• Nabilone Use in Pregnancy & Breastfeeding
• Nabilone Drug Interactions
• Nabilone Support Group
• 1 Review for Nabilone - Add your own review/rating

• Nabilone Professional Patient Advice (Wolters Kluwer)


• Nabilone Monograph (AHFS DI)


• Nabilone MedFacts Consumer Leaflet (Wolters Kluwer)


• Cesamet Prescribing Information (FDA)


• Cesamet Consumer Overview

Compare nabilone with other medications

• Fibromyalgia
• Nausea/Vomiting, Chemotherapy Induced

Solaraze

Generic Name: diclofenac topical (dye KLOE fen ak TOP ik al)

Brand Names: Pennsaid, Solaraze, Voltaren Topical

What is Solaraze (diclofenac topical)?

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Diclofenac topical 1% gel (Voltaren Topical) is used to treat joint pain in the hands, wrists, elbows, knees, ankles, or feet caused by osteoarthritis. This medication may not be effective in treating arthritis pain elsewhere in the body.

Diclofenac topical 1.5% solution (Pennsaid) is used to treat pain in the knees caused by osteoarthritis. This medication may not be effective in treating arthritis pain elsewhere in the body.

Diclofenac topical 3% gel (Solaraze) is used to treat warty overgrowths of skin (actinic keratoses) on sun-exposed areas of the body.

Diclofenac topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Solaraze (diclofenac topical)?

Do not use this medication if you have ever had asthma or a severe allergic reaction caused by aspirin, diclofenac (Cataflam, Voltaren), or another non-steroidal anti-inflammatory drug (NSAID). Do not use diclofenac just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Before using this medication, tell your doctor if you have heart disease, congestive heart failure, high blood pressure, a history of heart attack or stroke, a history of stomach ulcer or bleeding, liver or kidney disease, a blood clotting disorder, asthma, or nasal polyps.

While the risk of absorbing diclofenac topical into your bloodstream is low, an NSAID may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are using diclofenac topical, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What should I discuss with my healthcare provider before using Solaraze (diclofenac topical)?

While the risk of absorbing diclofenac topical into your bloodstream is low, an NSAID can cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are using diclofenac topical, especially in older adults.

Do not use this medication if you have ever had asthma or a severe allergic reaction caused by aspirin, diclofenac (Cataflam, Voltaren), or another NSAID. Do not use diclofenac just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

To make sure you can safely use diclofenac topical, tell your doctor if you have any of these other conditions:

• 
  

  a history of drug allergies;

  
  


• 
  

  a history of heart attack, stroke, or blood clot;

  
  


• 
  

  heart disease, congestive heart failure, high blood pressure;

  
  


• 
  

  a history of stomach ulcer or bleeding;

  
  


• liver or kidney disease;


• 
  

  a bleeding or blood clotting disorder; or

  
  


• 
  

  asthma, or polyps in your nose.

  
  

This medication may be harmful to an unborn baby. If you are pregnant, ask your doctor if it is safe for you to use diclofenac topical. Tell your doctor if you become pregnant during treatment. Diclofenac topical can pass into breast milk and may harm a nursing baby. You should not breast-feed while using diclofenac topical.

How should I use Solaraze (diclofenac topical)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. When treating osteoarthritis, keep using any oral medications your doctor has prescribed.

Do not use diclofenac topical on an open skin wound, or on areas of eczema, infection, skin rash, or burn injury. Do not cover the treated skin with a bandage or expose it to heat from a hot tub, heating pad, sauna, or heated water bed. Heat or bandaging can increase the amount of drug you absorb through your skin and may cause harmful effects. Wash your hands after applying this medication, unless you are treating the skin on your hands. Do not wear gloves for at least 10 minutes after applying diclofenac topical to the hands.

After you apply diclofenac topical gel, wait at least 10 minutes before dressing and at least 1 hour before you bathe or shower.

To treat actinic keratosis (with Solaraze): Apply enough gel to cover each lesion and rub in gently. Do not apply Solaraze gel more than 2 times daily and never use more than your prescribed dose.

To treat osteoarthritis knee pain (with Pennsaid): Apply the solution only to clean, dry skin. Place 10 drops at a time into your hand and spread the solution over the front, back, and sides of the knee. Apply a total of 40 drops to each affected knee, 4 times per day. You may also drop the medicine directly onto the knee, spreading after every 10 drops.

Wait until the solution is completely dry before covering treated skin with clothing or applying any other skin products, including sunscreen.

To treat osteoarthritis pain (with Voltaren Topical): This medicine is supplied with dosing cards that show you how much gel to use for a 2-gram dose or a 4-gram dose. Squeeze the gel onto this card along the line for your dose. Use no more gel than will fit on the length of your dosing line. Wipe the card directly onto the treatment area and rub gently into the skin.

To treat arthritis pain in the foot, spread the gel out onto all areas of the foot including the toes and soles. When treating the hand, spread the gel out onto all areas of the hand including the fingers and palms.

Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Solaraze (diclofenac topical)?

Avoid drinking alcohol. It may increase your risk of stomach bleeding. Do not use cosmetics, sunscreen, lotions, insect repellant, or other medicated skin products on the same area you treat with diclofenac topical. Avoid getting this medication in your mouth, nose, or eyes. If this does happen, rinse with water. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) while you are using diclofenac topical.

Avoid taking aspirin, oral (pill form) diclofenac (Cataflam, Voltaren), or other NSAIDs without your doctor's advice. This includes ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.

Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Aspirin and other medicines similar to diclofenac are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Solaraze (diclofenac topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when diclofenac is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain, slurred speech, problems with vision or balance, and feeling weak or short of breath;

  
  


• 
  

  bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  pale or yellowed skin, dark colored urine, confusion;

  
  


• 
  

  swelling or rapid weight gain, urinating less than usual or not at all;

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


• 
  

  bruising, severe tingling, numbness, pain, muscle weakness;

  
  


• 
  

  fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

  
  


• 
  

  the first sign of any skin rash, no matter how mild.

  
  

Less serious side effects may include:

• 
  

  mild nausea, stomach pain, upset stomach;

  
  


• 
  

  diarrhea, gas; or

  
  


• 
  

  mild itching, dryness, redness, scaling, or other skin irritation where the medicine was applied.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Solaraze (diclofenac topical)?

Tell your doctor about all other medicines you use, especially:

• 
  

  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  steroids (prednisone and others); or

  
  


• 
  

  heart or blood pressure medication such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others.

  
  

It is not likely that other drugs you take orally or inject will have an effect on topically applied diclofenac. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Solaraze resources

• Solaraze Side Effects (in more detail)
• Solaraze Use in Pregnancy & Breastfeeding
• Solaraze Drug Interactions
• Solaraze Support Group
• 0 Reviews for Solaraze - Add your own review/rating

• Solaraze Prescribing Information (FDA)


• Solaraze topical Monograph (AHFS DI)


• Solaraze Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Solaraze Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Pennsaid Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Pennsaid Prescribing Information (FDA)


• Pennsaid Consumer Overview

Compare Solaraze with other medications

• Actinic Keratosis

Where can I get more information?

• Your pharmacist can provide more information about diclofenac topical.

See also: Solaraze side effects (in more detail)

Sulfatol SS Cream

sulfacetamide sodium and sulfur

Dosage Form: cream
Sulfatol SS™ Cream with Sunscreens

Rx Only

PRODUCT DESCRIPTION

Each gram of Sulfatol SS Cream with Sunscreens contains 100 mg of sodium sulfacetamide and 50 mg of sulfur. Sulfacetamide sodium is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent sulfur.

Chemically, sulfacetamide sodium is Acetamide, N-[(4-aminophenyl) sulfonyl], monosodium salt, monohydrate. The structural formula is:

INACTIVE INGREDIENTS

Avobenzone USP, Benzyl Alcohol NF, Cetyl Alcohol NF, Cocoglycerides, Dimethicone 200/100, Edetate Disodium USP, Fragrance, Glyceryl Stearate/PEG-100 Stearate, Isopropyl Myristate NF, Light Mineral Oil NF, Octinoxate USP, Polysorbate 60 NF, Propylene Glycol USP, Purified Water USP, Sodium Thiosulfate USP, Sorbitan Monostearate NF, Stearyl Alcohol NF, Xanthan Gum NF.

Sulfatol SS Cream - Clinical Pharmacology

The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sulfacetamide sodium is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

INDICATIONS

Sulfatol SS™ Cream with Sunscreens is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

Contraindications

Sulfatol SS™ Cream with Sunscreens is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation. This product should not to be used by patients with kidney disease.

FOR EXTERNAL USE ONLY. Keep out of reach of children. Keep away from eyes. Keep away from mucous membranes. Keep tube tightly closed.

Warnings

Although rare, fatalities have occurred due to severe reactions to sulfonamides, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Hypersensitivity reactions may occur when a sulfonamide is readministered, irrespective of the route of administration. Sensitivity reactions have been reported in individuals with no prior history of sulfonamide hypersensitivity. At the first sign of hypersensitivity, skin rash or other reactions, discontinue use of this medication (see ADVERSE REACTIONS section).

Sulfacetamide sodium contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people (see CONTRAINDICATIONS section).

Precautions

General

If irritation develops, use of the product should be discontinued and appropriate therapy instituted. Patients should be carefully observed for possible local irritation or sensitization during long-term therapy. Hypersensitivity reactions may occur when a sulfonamide is readministered irrespective of the route of administration, and cross-sensitivity between different sulfonamides may occur. Sulfacetamide sodium can cause erythema (redness) and scaling of the skin. Particular caution should be employed if areas of involved skin to be treated are denuded or abraded.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term studies in animals have not been performed to evaluate carcinogenic potential.

Pregnancy

Category C

Animal reproduction studies have not been conducted with sulfacetamide sodium. It is also not known whether sulfacetamide sodium can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sulfacetamide sodium should be given to a pregnant woman only if clearly needed. Kernicterus may occur in the newborn as a result of treatment of a pregnant woman at term with orally administered sulfonamide. There are no adequate and well-controlled studies of sulfacetamide sodium in pregnant women, and it is not known whether topically applied sulfonamides can cause fetal harm when administered to a pregnant woman.

Nursing Mothers

It is not known whether sulfacetamide sodium is excreted in human milk following topical use of sulfacetamide sodium. Systemically administered sulfonamides are capable of producing kernicterus in the infants of lactating women. Small amounts of orally administered sulfonamides have been reported to be eliminated in human milk. Because many drugs are excreted in human milk, caution should be exercised in prescribing for nursing women.

Pediatric Use

Safety and effectiveness in children under 12 years of age has not been established.

Adverse Reactions

Although rare, sulfacetamide sodium may cause local irritation, including stinging and burning. Other adverse events associated with the use of sulfacetamide sodium are as follows: Erythema (redness), itching and edema.

Directions

Cleanse affected areas. Apply a thin film 1 to 3 times daily, or as directed by a physician.

How is Sulfatol SS Cream Supplied

Sulfatol SS™ Cream with Sunscreens (sulfacetamide sodium 10% and sulfur 5%) is supplied in 45 g tubes. NDC 51991-302-45

Storage

Store at 25° C (77° F); excursions permitted to 15°-30° C (59°-86° F). See USP Controlled Room Temperature. Protect from freezing.

Dispense in original container.

Warning

Keep this and all medications out of the reach of children. In case of accidental overdose, seek professional assistance or contact a poison control center immediately.

All prescription substitutions using this product shall be pursuant to state statutes as applicable. This is not an Orange Book product.

Manufactured by: Groupe Parima Inc., Montréal, QC Canada H4S 1X6

Distributed by: Breckenridge Pharmaceutical, Inc., Boca Raton, FL 33487

Iss: 2/09

PRINCIPAL DISPLAY PANEL - 45 g Tube Carton

Breckenridge

Pharmaceutical, Inc.

NDC 51991-302-45

Sulfatol SS™ Cream with Sunscreens

Sulfacetamide Sodium 10% and Sulfur 5%

Rx Only

Net Wt. 45 g

For The Topical Control Of

• Acne Vulgaris


• Acne Rosacea


• Seborrheic Dermatitis

SULFATOL SS  sulfacetamide sodium and sulfur  cream

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 51991-302 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Sulfacetamide Sodium (Sulfacetamide) Sulfacetamide Sodium 100 mg  in 1 g Sulfur (Sulfur) Sulfur 50 mg  in 1 g

Inactive Ingredients Ingredient Name Strength Avobenzone   Benzyl Alcohol   Cetyl Alcohol   Coco-glycerides   Dimethicone   Edetate Disodium   Glyceryl Monostearate   Polyoxyl 100 Stearate   Isopropyl Myristate   Light Mineral Oil   Octinoxate   Polysorbate 60   Propylene Glycol   Water   Sodium Thiosulfate   Sorbitan Monostearate   Stearyl Alcohol   Xanthan Gum

Product Characteristics Color YELLOW (light-yellow) Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 51991-302-45 1 TUBE In 1 BOX contains a TUBE 1 45 g In 1 TUBE This package is contained within the BOX (51991-302-45)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
UNAPPROVED DRUG OTHER		08/01/2009	02/28/2011

Labeler - Breckenridge Pharmaceutical, Inc. (150554335)

Establishment
Name	Address	ID/FEI	Operations
Groupe Parima		252437850	MANUFACTURE

Revised: 05/2010Breckenridge Pharmaceutical, Inc.

More Sulfatol SS Cream resources

• Sulfatol SS Cream Side Effects (in more detail)
• Sulfatol SS Cream Use in Pregnancy & Breastfeeding
• Sulfatol SS Cream Drug Interactions
• 0 Reviews for Sulfatol SS - Add your own review/rating

Compare Sulfatol SS Cream with other medications

• Acne
• Rosacea
• Seborrheic Dermatitis